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HDM2 antagonist JNJ-26854165 inhibits the binding of the HDM2–p53 complex to the proteasome
At 10 μM concentration
critrevonc
as well as the release of TNF-α from peripheral blood mononuclear cells treated with the superantigen staphylococcal enterotoxin B
C2HF3O2/c1-9-16(10(2)23-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(25)24-26
Asymmetric dimethylarginine 14145 hydrochloride HDM2 antagonist JNJ-26854165 inhibits theAsymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. Product information CAS Number: 30315 93 6 Molecular Weight: 202. 25 Formula: C8H18N4O2 Chemical Name: (2S) 2 amino 5 (N',N' dimethylcarbamimidamido)pentanoic acid Smiles: CN(C)C(=N)NCCC[C@H](N)C(O)=O InChiKey: YDGMGEXADBMOMJ LURJTMIESA N InChi: InChI=1S C8H18N4O2 c1