7-Acetylintermedine - CAS# 74243-01-9 instat hydrochloride 2011 Nov 3

2011 Nov 3

TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade

GNE-272 does not inhibit any target at >30%

heterobifunctional small-molecule BET degraders have been designed based upon the proteolysis targeting chimera (PROTAC) concept to induce BET protein degradation

30)/b21-15+

7-Acetylintermedine - CAS# 74243-01-9 instat hydrochloride 2011 Nov 37 Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid. Product information CAS Number: 74243 01 9 Molecular Weight: 341. 40 Formula: C17H27NO6 Chemical Name: [(1R,7aR) 1 (acetyloxy) 2,3,5,7a tetrahydro 1H pyrrolizin 7 yl]methyl (2S) 2 hydroxy 2 [(1R) 1 hydroxyethyl] 3 methylbutanoate Smiles: CC(=O)O[C@@H]1CCN2CC=C(COC(=O)[C@@](O)([C@@H](C)O)C(C)C)[C@@H]21 InChiKey: RKDOFSJTBIDAHX CYHLAULCSA N InChi: InChI=1S C17H27NO6 c1