TAK-779 Catalog No.:M10030-10 CAS Number: 55981-09-4

CAS Number: 55981-09-4

Smiles: CC1=CC(NC2N=CC(Cl)=C(NC3=CC=CC=C3S(=O)(=O)C(C)C)N=2)=C(C=C1C1CCNCC1)OC(C)C

In GDC-0879 treated mice

Janeta Popovici-Muller

Jinnin M et al

TAK-779 Catalog No.:M10030-10 CAS Number: 55981-09-4TAK 779 is a C C chemokine receptor type 5 (CCR5) receptor antagonist potentially for the treatment of HIV infection. Treatment with TAK 779 reduced incidence and severity of experimental autoimmune encephalomyelitis. It strongly inhibited migration of CXCR3 CCR5 bearing CD4+, CD8+ and CD11b+ leukocytes to the CNS. TAK 779 did not reduce proliferation of anti myelin oligodendrocyte glycoprotein T cells, the production of IFN gamma by T cells or CXCR3