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O=C1NC(=O)C(=C1C1=CN2CCNCC3=CC(F)=CC1=C23)C1=CN=C2C=CC=CN21
potent and cell-permeable inhibitor of p38 MAP kinase
ON-01910 is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity
InChi: InChI=1S/C27H29FN2O3/c28-25-18-22(13-11-20(25)12-14-27(31)32)29-19-21-6-4-10-26-24(21)9-5-15-30(26)16-17-33-23-7-2-1-3-8-23/h1-4
Formula: C35H34F6N4O7
M-110 0192 O=C1NC(=O)C(=C1C1=CN2CCNCC3=CC(F)=CC1=C23)C1=CN=C2C=CC=CN21M 110 is a inhibitor of protein arginine N methyltransferases (PRMTs). It is also a highly isoform selective, cell permeable and potent ATP competitive inhibitor of the PIM kinase family that prefers PIM 3, shown to inhibit the proliferation of prostate cancer cell lines with IC50s between 0. 6 to 0. 9 M, with no activity on normal human peripheral blood mononuclear cells up to 40 M. Product information CAS Number: 1395048 49 3 Molecular Weight: 445.