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Significant efficacy can be achieved with GS-9876 doses that produces trough pSYK inhibition of <50%
Solubility: DMSO : 100 mg/mL (432
287(13):9742-52
C7H9N/c9-4-1-2-5-7(8(4)10)6(3-11-5)15-16(12
SN-2 is a selective TRPML3 channel activator
D-erythro-MAPP - CAS# 143492-38-0 16435 Significant efficacy can be achievedD erythro MAPP (D e MAPP) is a ceramidase inhibitor, with an IC50 of 1 5 M in vitro. Product information CAS Number: 143492 38 0 Molecular Weight: 361. 56 Formula: C23H39NO2 Chemical Name: N [(1S, 2R) 1 hydroxy 1 phenylpropan 2 yl]tetradecanamide Smiles: C[C@@H](NC(=O)CCCCCCCCCCCCC)[C@@H](O)C1C=CC=CC=1 InChiKey: YLAZEWZHIRBZDA NFBKMPQASA N InChi: InChI=1S C23H39NO2 c1 3 4 5 6 7 8 9 10 11 12 16 19 22(25)24 20(2)23(26)21 17 14 13 15 18 21 h13 15,17