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modestly reduces in mean channel open time
Akt in HER2 overexpressing cell lines
It Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1
cyclic peptidomimetic that has been shown to be a partial TrkA receptor agonist
Smiles: COC1=CC(/C=C/C(=O)OCC2C=CC(=CC=2)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=CC=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
MG-277 164015 modestly reduces in mean channelMG 277, a molecular glue degrader, effectively induces degradation of a translation termination factor, GSPT1, with a DC50 of 1. 3 nM. MG 277 potently inhibits tumor cell growth in a p53 independent manner, with IC50s of 3. 5 nM for RS4; 11 cells and 3. 4 nM for p53 mutant RS4; 11 IRMI 2 cells, respectively. Anticancer activity. Product information CAS Number: 2411085 89 5 Molecular Weight: 774. 71 Formula: C41H42Cl2FN5O5 Chemical Name: (3'R,4'S,5'R)
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